Newcastle Central Vein and Cosmetic Medical Centre

Persistent Chlamydophila Pneumoniae (CPn) Infection In Multiple Sclerosis and Chronic Cerebrospinal Venous Insufficiency (CCSVI)


The following is an Information Pack consisting of frequently asked questions and a treatment protocol for infection with CPn, implicated in Multiple Sclerosis and CCSVI.















Thibault Protocol (Combined Antibiotic Protocol)
Modified Wheldon Protocol (CAP) for Persistent Chlamydophila Pneumoniae (CPn)
Infection Associated with MS/CCSVI



  • Minocycline 100mg twice daily. If you suffer from vertigo taking Minocycline then try Pyridoxine (Vitamin B6) 100mg twice daily with the Minocycline. The alternative to Minocycline is Doxycycline 100mg twice daily. Lower doses may be advised for lower body weights.


  • N-Acetyl-Cysteine (NAC) 1200mg twice daily. Initial dose should be 600mg once daily increasing slowly to 1200mg twice daily when tolerating well.


  • Roxithromycin 150mg twice daily commencing 1 month after starting Minocycline or Doxycycline.


  • Tinidazole 500mg twice a day for 2 days once a month starting 3 months after commencement of Minocycline or Doxycycline. The first “pulse” should be just 1x500mg tablet, and in the second month take 2x500mg tablets. Then in the third month take the full dose. Metronidazole is an alternative to Tinidazole. After 6 months the interval between pulses may be reduced to 2 or 3 weeks.


  • Diet – Complex carbohydrate, low fat diet (paleolithic) avoiding milk and red meats. Plenty of fluids. Avoid alcohol. This is similar to the “Swank” diet.


  • Aspirin (Cartia) 100mg daily. This can be changed to Nattokinase, one capsule twice daily, after 6 months. Aspirin needs to be stopped at least 1 week before starting Nattokinase.


  • The initial treatment is generally for 12 months. After that treatment may be reduced to intermittent if deemed to be appropriate, but the NAC should be taken indefinitely to help prevent re-infection.

Further information on the CPn CAP protocol is available at: